ドクタープロフィール

著　書
1）林　孝彦、水木信久 （分担執筆）基礎からわかるぶどう膜炎 感染性ぶどう膜炎3）ヘルペス性虹彩毛様体炎: 247-52 金原出版, 東京, 2006
2）林　孝彦、水木信久 （分担執筆）トピックス：炎症性眼疾患とHLA分子の相関　眼科プラクティス（16), 「眼内炎症診療のこれから」文光堂, 東京　2007:　41-43
3）林　孝彦、加藤　直子　オクリスタ，「角膜移植拒絶反応の予防」 全日本病院出版，東京　2016;42: 54-60
4）林　孝彦　眼科，「DMEK～成功の秘訣」　金原出版，東京　2017; 59: 499-508

総　説
1）Hayashi T, Mizuki N.
Ocular manifestation in Behcet’s Disease JAMAJ2006; 49: 260-268. Review.
2）林　孝彦、水木信久
眼薬剤アレルギーと免疫　日本の眼科2006; 77: 111-116. 総説
3）林　孝彦、水木信久
HLA分子と全身疾患　あたらしい眼科2006; 23: 1547-1557. 総説

原　著
Ⅰ）原著：
1）林　孝彦、磯部淑恵、佐々木　爽、伊藤典彦、石岡みさき、中川　尚、秦野　寛、水木信久　慢性移植片対宿主反応の経過中に角膜ヘルペスを発症した1症例. あたらしい眼科2006;23: 1467-1469.
2）Hayashi T, Inoko H, Nishizaki R, Ohno S, Mizuki N.　Exclusion of transforming growth factor-beta1 as a candidate gene for myopia in the Japanese. Jpn J Ophthalmol 2007; 51: 96-99.
3）Teshigawara T, Hata S, Hayashi T, Watanabe Y, Itoh N, Mizuki N.　Penetration of gatifloxacin eye drops into the aqueous humor in humans. Ocul Immunol Inflamm 2007; 15: 309-313.
4）Hayashi T, Ishioka M, Itho N, Kato Y, Nakagawa H, Hatano H, Mizuki N. Bilateral herpes simplex keratitis in a patient with chronic graft-versus-host disease. Clinical Ophthalmology 2008; 2, 457-459.
5）Hayashi T, Yamagami S, Tanaka K, Yokoo S, Usui T, Amano S, Mizuki N. A mouse model of corneal endothelial cell transplantation. Cornea 2008; 27: 699-705.
6）加藤 陽子、中川 尚、秦野 寛、大野 智子、林 孝彦、佐々木 爽、水木 信久 学童におけるオルソケラトロジー経過中に発症したアカントアメーバ角膜炎の1例．あたらしい眼科2008; 25: 101-103.
7）Hayashi T, Yamagami S, Tanaka K, Yokoo S, Usui T, Amano S, Mizuki N. Immunologic mechanisms of corneal allografts reconstituted from cultured allogeneic endothelial cells in an immune-privileged site. Invest Ophthalmol Vis Sci 2009; 50: 3151-3158.
8）Albuquerque RJ, Hayashi T, Cho WG, Kleinman ME, Dridi S, Takeda A, Baffi JZ, Yamada K, Kaneko H, Green MG, Chappell J, Wilting J, Weich HA, Yamagami S, Amano S, Mizuki N, Alexander JS, Peterson ML, Brekken RA, Hirashima M, Capoor S, Usui T, Ambati BK, Ambati J. Alternatively spliced vascular endothelial growth factor receptor-2 is an essential endogenous inhibitor of lymphatic vessel growth. Nature Med 2009; 15: 1023-1030.
9）Hayashi T, Watanabe K, Tsuura Y, Tsuji G, Koyama S, Yoshigi J, Hirata N, Yamane S, Iizima Y,Toyota S, Takeuchi S. Sight-threatening optic neuropathy is associated with paranasal lymphoma. Clin Ophthalmol 2010; 24: 143-146.
10）Hayashi T, Hirayama Y, Yamada N, Shimazaki-Den S, Shimazaki J.　Descemet　stripping automated endothelial 　keratoplasty for bullous keratopathy with an　irregular posterior surface. Cornea 2013; 32: 1183-1188.
11） Hayashi T, Usui T, Yamagami S. Suppression of Allograft Rejection with Soluble VEGF Receptor 2 Chimeric Protein in a Mouse Model of Corneal Transplantation. Tohoku J Exp Med 2016; 239: 81-88
12） Hayashi T, Oyakawa I, Kato N. Techniques for Learning Descemet Membrane Endothelial Keratoplasty for Eyes of Asian Patients With Shallow Anterior Chamber. Cornea 2016; 36:　390-393.
13） Hayashi T, Oyakawa I, Kato N.　Eventual Endothelial Failure After Initial Corneal Clearing After a Detached Endothelial Graft in Fuchs Dystrophy. Cornea. 2017; 36: e9-e10. doi:10.1097/ICO.0000000000001146.
14） Shimizu T, Hayashi T, Yuda K, Tsuchiya A, Oyakawa I, Mizuki N, Kato N.Chandelier Illumination for Descemet Membrane Endothelial Keratoplasty. Cornea. 2017; 36: 1155-1157. doi: 10.1097/ICO.0000000000001254.
15）Hayashi T, Yuda K, Oyakawa I, Kato N. Use of Brilliant Blue G in Descemet’s Membrane Endothelial Keratoplasty. Biomed Res Int. 2017;2017:9720389. doi: 10.1155/2017/9720389.
16） Matsuzawa A, Hayashi T, Oyakawa I Yuda K, Shimizu T, Mizuki N, Yamada N, Kato N. Use of four asymmetric marks to orient the donor graft during Descemet’s membrane endothelial keratoplasty. BMJ open ophthalmol. 2017; DOI: 10.1136/bmjophth-2017-000080.
17） Ishido T, Horita N, Takeuchi M, Kawagoe T, Shibuya E, Yamane T, Hayashi T, Meguro A, Ishido M, Minegishi K, Yoshimi R, Kirino Y, Kato S, Arimoto J, Ishigatsubo Y, Takeno M, Kurosawa M, Kaneko T, Mizuki N. Clinical manifestations of Behcet’s disease depending on sex and age: results from Japanese nationwide registration.Rheumatology （Oxford). 2017; 56: 1918-1927. doi: 10.1093/rheumatology/kex285.
18） Hayashi T, Yamaguchi T, Yuda K, Kato N, Satake Y, Shimazaki J. Topographic Characteristics after Descemet’s Membrane Endothelial Keratoplasty and Descemet’s Stripping Automated Endothelial Keratoplasty. Plos One. 2017;12:e0188832. doi: 10.1371/journal.pone.0188832. eCollection 2017.
19）Matsuzawa A, Hayashi T, Oyakawa I, Yuda K, Shimizu T, Mizuki N, Yamada N, Kato N. Use of four asymmetric marks to orient the donor graft during Descemet’s membrane endothelial keratoplasty. BMJ Open Ophthalmol. 2017 Aug 4;1（1):e000080.
doi: 10.1136/bmjophth-2017-000080. eCollection 2017. PubMed PMID: 29354713;
PubMed Central PMCID: PMC5721642.
20）Oyakawa I, Hayashi T, Shimizu T, Kato N. Modified Descemet’s Stripping Automated Endothelial Keratoplasty: The Use of Ophthalmic Viscoelastic Devices in Hypotonic Eyes That Had Undergone Glaucoma Filtering Surgeries. Case Rep
Ophthalmol Med. 2018 Feb 1;2018:9387810. doi: 10.1155/2018/9387810. eCollection 2018. PubMed PMID: 29487754; PubMed Central PMCID: PMC5816860.
21）Hayashi T. Mechanism of Immunologic Rejection After Deep Anterior Lamellar Keratoplasty. Cornea. 2018 Jun;37（6):e30. doi: 10.1097/ICO.0000000000001574. PubMed PMID: 29521693.
22）Hayashi T, Kobayashi A. Double-Bubble Technique in Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes: A Case Series. Cornea. 2018 Sep;37（9):1185-1188. doi: 10.1097/ICO.0000000000001606. PubMed PMID: 29634673.
23）Yamada N, Hayashi T, Yuda K, Shimizu T, Oyakawa I, Takahashi H, Kato N. Outcomes of Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes with Sutured Posterior Chamber Intraocular Lens. J Ophthalmol. 2018 Apr 11;2018:3127126. doi: 10.1155/2018/3127126. eCollection 2018. PubMed PMID: 29850201; PubMed Central PMCID: PMC5925161.
24）Hayashi T, Oyakawa I, Matsuzawa A, Yuda K, Shimizu T, Tsuchiya A, Mizuki N, Kato N. Descemet membrane endothelial keratoplasty using ophthalmic viscoelastic devices for eyes with laser iridotomy-induced corneal endothelial decompensation: Analysis of 11 eyes. Medicine （Baltimore). 2018 Jun;97（26):e11245. doi: 10.1097/MD.0000000000011245. PubMed PMID: 29952990; PubMed Central PMCID:
PMC6039634.
25）Shimizu T, Hayashi T, Yuda K, Takahashi H, Oyakawa I, Yamazaki K, Mizuki N, Kato N. Short Axial Length and Iris Damage Are Associated With Iris Posterior Synechiae After Descemet Membrane Endothelial Keratoplasty in Asian Eyes. Cornea.
2018 Nov;37（11):1355-1359. doi: 10.1097/ICO.0000000000001698. PubMed PMID: 30004959.
26）Oyakawa I, Hayashi T, Kobashigawa Y, Matsuzawa A, Takahashi H, Kato N. Evaluation of Anterior and Posterior Corneal Irregularity After Descemet Membrane Endothelial Keratoplasty. Cornea. 2018 Nov;37（11):1360-1365. doi: 10.1097/ICO.0000000000001722. PubMed PMID: 30124590.
27）Yuda K, Shimizu T, Hayashi T, Yuda K. Sutureless Intrascleral Intraocular Lens Fixation Using a Microtube-Assisted Technique. Retina. 2019 Apr 10. doi: 10.1097/IAE.0000000000002371. [Epub ahead of print] PubMed PMID: 30395044.
28）Yousefi S, Yousefi E, Takahashi H, Hayashi T, Tampo H, Inoda S, Arai Y, Asbell P. Keratoconus severity identification using unsupervised machine learning. PLoS One. 2018 Nov 6;13（11):e0205998. doi: 10.1371/journal.pone.0205998. eCollection
2018. PubMed PMID: 30399144; PubMed Central PMCID: PMC6219768.
29）Inoda S, Hayashi T, Takahashi H, Oyakawa I, Yokogawa H, Kobayashi A, Kato N, Kawashima H. Risk Factors for Cystoid Macular Edema After Descemet Membrane Endothelial Keratoplasty. Cornea. 2019 Jul;38（7):820-824. doi: 10.1097/ICO.0000000000001950. PubMed PMID: 30973407.
30）Yuda K, Kato N, Takahashi H, Shimizu T, Oyakawa I, Matsuzawa A, Yuda K, Hayashi T. Effect of Graft Shift Direction on Graft Detachment and Endothelial Cell Survival After Descemet Membrane Endothelial Keratoplasty. Cornea. 2019 May 23. doi: 10.1097/ICO.0000000000002015. [Epub ahead of print] PubMed PMID:
31135493.
31）Tase S, Shimizu T, Hayashi T, Tabuchi H, Niimi K, Mizuki N, Kato N. Descemet’s membrane endothelial keratoplasty for pseudoexfoliation syndrome: a case series. BMC Ophthalmol. 2019 May 28;19（1):119. doi: 10.1186/s12886-019-1130-1. PubMed
PMID: 31138243; PubMed Central PMCID: PMC6537358.

学会発表
1）林　孝彦 マウス水疱性角膜症眼に対するアロ角膜内皮細胞移植とアロ全層角膜移植の免疫反応 第31回角膜カンファレンス, 平成19年2月10日, 宮崎市　（北野賞受賞)
2）Hayashi, T. Characterization of Immune Response in Mouse Corneal Endothelial Cell Transplantation. The Association for Research in Vision and Ophthalmology, May 6th, 2007, Fort Lauderdale, Florida, U.S.A.
3）林　孝彦 「角膜内皮移植の免疫的特徴～拒絶反応ゼロの角膜移植～」
～シンポジウム10，眼の炎症の謎を解く～
第115回日本眼科学会総会, 平成23年5月13日, 東京
4）Hayashi T, Oyakawa I, Matsuzawa A, Yuda K, Kato N. Descemet membrane endothelial keratoplasty using ophthalmic viscoelastic devices for Asian eyes with shallow anterior chambers Eu Cornea, 7th Oct, 2017, Lisbon, Portugal.
5）Yuda K, Hayashi T, Oyakawa I, Kato N. Use of brilliant blue G for graft staining during descemet’s membrane endothelial keratoplasty. Eu Cornea, 7th Oct, 2017, Lisbon, Portugal.
6）Matsuzawa A, Hayashi T, Oyakawa I, Yamada N, Kato N, Takagi T. The use of four asymmetric marks to orient the donor graft during descemet’s membrane endothelial keratoplasty Eu Cornea, 7th Oct, 2017, Lisbon, Portugal.
7）Yamada N, Hayashi T, Yuda K, Ishikawa S, Yamazaki K, Kato N. Descemet membrane endothelial keratoplasty （DMEK）after transscleral-sutured posterior chamber intraocular lens implantation and pars plana vitrectomy. Eu Cornea, 7th Oct, 2017, Lisbon, Portugal.
8）林　孝彦 「水疱性角膜症にDMEK」
～シンポジウム5，角膜治療の最新の進歩～
第71回日本臨床眼科学会，平成28年10月12日，東京

教育実績
横浜市立大学非常勤講師（2014年4月～)
同臨床准教授（2018年4月)
埼玉医科大学非常勤講師（平成2７年4月～現在に至る)
聖マリアンナ医科大学非常勤講師（平成27年9月～現在に至る)
自治医科大学非常勤講師（平成29年4月～現在に至る)
大学院生（現在就学中)の指導；Corresponding author2本

受　賞
第31回角膜カンファレンス, 平成19年2月10日, 宮崎市　（北野賞受賞)

加入学会
日本眼科学会、角膜学会、角膜移植学会、日本眼科手術学会

その他（外部資金獲得等）
2009 – 2010年，培養角膜内皮細胞を用いた拒絶反応のない理想的な角膜移植術の開発，若手（B)，4,420千円，（研究課題/領域番: 21791698)